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| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | S6K1 rabbit polyclonal antibody |
Gene Name: | Ribosomal protein S6 kinase beta-1 |
Synonyms: | S6K-beta-1, S6K1, P70S6K1, S6K, Ribosomal protein S6 kinase I, P70 S6 kinase alpha, Rps6kb1, 70 kDa ribosomal protein S6 kinase 1 |
Immunogen: | Recombinant protein corresponding to Human S6K1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Uniprot ID: | P23443, Q8BSK8, P67999 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 600-1: 2000 | liver, liver cancer, lung cancer |
Background
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex.
Images
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Immunohistochemistry of paraffin embedded human liver using P70S6K1 (GB111181) at dilution of 1:1200 (400x lens) |
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Immunohistochemistry of paraffin embedded human liver cancer using P70S6K1 (GB111181) at dilution of 1:1200 (400x lens) |
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Immunohistochemistry of paraffin embedded human lung cancer using P70S6K1 (GB111181) at dilution of 1:1200 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
