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Anti-SAMHD1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SAMHD1 rabbit polyclonal antibody |
Gene Name: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 |
Synonyms: | dNTPase, Interferon-gamma-inducible protein Mg11, Samhd1, Mg21, SAM domain and HD domain-containing protein 1, mSAMHD1 |
Immunogen: | Recombinant protein corresponding to Mouse SAMHD1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. | 76 kDa |
Observed MW. | 72 kDa |
Uniprot ID: | Q9Y3Z3, Q60710 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain |
IHC/IF | Human, Mouse, Rat | 1: 1000-1: 4000 | brain, colon, heart, kidney, lung, placenta, renal cancer, small intestine, spleen, testis |
Background
The SAMHD1 is a putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. It is a host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.
Images
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Western blot analysis of SAMHD1 (GB111331) at dilution of 1: 500 |
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Immunohistochemistry of paraffin embedded human colon using SAMH01 (GB111331) at dilution of 1: 2000 (400x lens) |
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Immunohistochemistry of paraffin embedded human renal cancer using SAMH01 (GB111331) at dilution of 1: 2000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse brain using SAMH01 (GB111331) at dilution of 1: 2000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse heart using SAMH01 (GB111331) at dilution of 1: 2000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse lung using SAMH01 (GB111331) at dilution of 1: 2000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse testis using SAMH01 (GB111331) at dilution of 1: 2000 (300x lens) |
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Immunohistochemistry of paraffin embedded rat brain using SAMH01 (GB111331) at dilution of 1: 2000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat heart using SAMH01 (GB111331) at dilution of 1: 2000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat liver using SAMH01 (GB111331) at dilution of 1: 2000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat lung using SAMH01 (GB111331) at dilution of 1: 2000 (400x lens) |
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Immunofluorescence of paraffin embedded human renal cancer using SAMH01 (GB111331) at dilution of 1: 1100 (400x lens) |
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Immunofluorescence of paraffin embedded mouse lung using SAMH01 (GB111331) at dilution of 1: 1100 (400x lens) |
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Immunofluorescence of paraffin embedded mouse small intestine using SAMH01 (GB111331) at dilution of 1: 1100 (400x lens) |
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Immunofluorescence of paraffin embedded rat placenta using SAMH01 (GB111331) at dilution of 1: 1100 (400x lens) |
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Immunofluorescence of paraffin embedded rat spleen using SAMH01 (GB111331) at dilution of 1: 1100 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
