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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Serine/arginine-rich splicing factor 2 |
Synonyms: | PR264, Protein PR264, SC 35SFRS2, SFRS2A, Splicing component, 35 kDa, Splicing factor SC35, SRp30b, SRSF2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SC35 |
Uniprot ID: | Q62093 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 25 kDa / 37 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 300-1: 1000 | fetal brain |
Background
Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Can bind to the myelin basic protein (MBP) gene MB3 regulatory region and increase transcription of the mbp promoter in cells derived from the CNS. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.
Images
| Western blot analysis of SFRS2 (GB115009) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
