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Anti-SCN4B Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SCN4B rabbit polyclonal antibody |
Gene Name: | Sodium channel subunit beta-4 |
Synonyms: | Scn4b, Gm1471, sodium channel, voltage gated, type IV beta subunit, voltage-gated, LQT10, Navbeta4, ATFB17 |
Immunogen: | Recombinant protein corresponding to Mouse SCN4B |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Uniprot ID: | Q7M729, Q7M730 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 2000-1: 4000 | brain, heart |
Background
The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart.
Images
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Immunohistochemistry of paraffin embedded mouse brain using SCN4b (GB111596) at dilution of 1:2000 (300x lens) |
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Immunohistochemistry of paraffin embedded rat heart using SCN4b (GB111596) at dilution of 1:2000 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
