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Anti-SH3PXD2A Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | SH3 and PX domain-containing protein 2A |
Synonyms: | Adapter protein TKS5, FISH, KIAA0418, SH3 and PX domains 2A, SH3 multiple domains protein 1, SH3MD1, SH3PXD2A, TKS5 |
Immunogen: | Recombinant protein corresponding to Mouse SH3PXD2A |
Uniprot ID: | O89032 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Product Usage Information
IHC/IF | Human | 1: 500-1: 1500 | endometrial carcinoma, gastric cancer |
Background
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
Images
| Immunohistochemistry analysis of paraffin embedded human endometrial carcinoma using SH3PXD2A (GB115380) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human gastric cancer using SH3PXD2A (GB115380) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
