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Anti-SHIP-1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SHIP1 rabbit polyclonal antibody |
Gene Name: | Phosphatidylinositol3,4,5-trisphosphate 5-phosphatase 1 |
Synonyms: | SIP-145, hp51CN, p150Ship, inositol, SHIP1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SHIP1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cytoplasm |
Uniprot ID: | Q9ES52, P97573 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 200-1: 1000 | lymph node, spleen, thymus |
Background
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems.
Images
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Immunohistochemistry of paraffin embedded mouse spleen using SHIP (GB11332) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded rat spleen using SHIP (GB11332) at dilution of 1:500 (400x lens) |
| Immunofluorescence of paraffin embedded rat lymph node using SHIP (GB11332) at dilution of 1:200 (400x lens) |
| Immunofluorescence of paraffin embedded rat spleen using SHIP (GB11332) at dilution of 1:200 (400x lens) |
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Immunofluorescence of paraffin embedded rat thymus using SHIP (GB11332) at dilution of 1:200 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
