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| Reactivity: | R & R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SHP2 rabbit polyclonal |
Gene Name: | Tyrosine-protein phosphatase non-receptor type 11 |
Synonyms: | SHP2, PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, Protein tyrosine phosphatase, non-receptor type 11 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SHP2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Rat | 1: 1000-1: 2000 | lung, colon |
IF | Rat | 1: 500-1: 1000 | lung, colon |
Background
PTPN11 is a protein tyrosine phosphatase (PTP) Shp2. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Images
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Immunohistochemistry analysis of paraffin-embedded rat lung using SHP2 (GB11698) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded rat colon using SHP2 (GB11698) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
