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Anti-SIGLEC5 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SIGLEC5 rabbit polyclonal antibody |
Gene Name: | Sialic acid-binding Ig-like lectin 5 |
Synonyms: | Siglec-5, Sialic acid-binding Ig-like lectin F, Siglec-F, mSiglec-F, CD33L2, OB-binding protein 2, Sialic acid-binding Ig-like lectin F, OBBP2, CD170 antigen |
Immunogen: | Recombinant protein corresponding to Mouse SIGLEC5 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 61 kDa |
Observed MW. | 70 kDa |
Uniprot ID: | O15389 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human | 1: 500-1: 1000 | HL-60, K562, NCI-H1299, U266 |
Background
SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. This protein binds equally to alpha2,3-linked and alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. This molecule is expressed by monocytic/myeloid lineage cells. SIGLEC5 is found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. It is expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.
Images
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Western blot analysis of Siglec5 (GB111590) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
