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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SIK1 rabbit polyclonal antibody |
Gene Name: | Serine/threonine-protein kinase SIK1 |
Synonyms: | HRT-20, Myocardial SNF1-like kinase, Serine/threonine-protein kinase SNF1-like kinase 1, Salt-inducible kinase 1, SIK1 |
Immunogen: | Recombinant protein corresponding to Mouse SIK1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 85 kDa |
Observed MW. | 90 kDa |
Uniprot ID: | Q60670, Q9R1U5 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | stomach, lung, ovary, heart |
Background
SIK1(Salt-inducible kinase 1) is also named as SIK, SNF1LK and belongs to the CAMK Ser/Thr protein kinase family. It associates constitutively with the NK regulatory complex and is responsible for increases in its catalytic activity following small elevations in intracellular sodium concentrations. SIK1 is required for phosphorylation of class II HDACs and for expression of MEF2 target genes in myocytes. Defects in SIK1 may be associated with some cancers, such as breast cancers. Loss of SIK1 correlates with poor patient outcome in breast cancers.
Images
| Western blot analysis of Msk (GB111034) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
