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Anti-SIRP alpha Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | signal-regulatory protein alpha |
Synonyms: | BIT, CD172A, Inhibitory receptor SHPS 1, Macrophage fusion receptor, MFR, MYD 1, MyD 1 antigen, MYD1, P84, PTPNS1, SHP substrate 1, SHPS 1, SHPS1, SIRP, SIRP alpha, SIRP ALPHA 1, SIRPA, SIRPalpha |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SIRP alpha |
Uniprot ID: | P97797 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 56 kDa /120 kDa(mouse)/100 kDa(Rat) |
Product Usage Information
WB | Mouse, Rat | 1: 500-1: 1000 | brain, spleen |
Background
Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.
Images
| Western blot analysis of SIRPa (GB114325) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
