Your shopping cart is empty!
Anti-SIRT6 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | NAD-dependent protein deacetylase sirtuin-6 |
Synonyms: | SIR2 like protein 6, SIR2L6, SIRT6 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SIRT6 |
Uniprot ID: | P59941 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 37 kDa / 40 kDa |
Product Usage Information
WB | Human | 1: 300-1: 500 | Hela, K562 |
Background
NAD-dependent protein deacetylase involved in various processes including telomere maintenance and gene expression, and consequently has roles in genomic stability, cell senescence and apoptosis Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate (By similarity). Has deacetylase activity towards histone H3K9Ac and H3K56Ac Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle (By similarity). May also be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance (By similarity). Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes
Images
| WB analysis of Sirt6 (GB115525). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
