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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SIRT7 rabbit polyclonal |
Gene Name: | NAD-dependent protein deacetylase sirtuin-7 |
Synonyms: | SIRT7, SIR2L7, sirtuin 7, SIR2 like protein 7, Regulatory protein SIR2 homolog 7, Sir2 related protein type 7 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SIRT7 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 200-1: 400 | tonsil, lung cancer, stomach cancer |
IF | Human | 1: 200-1: 400 | tonsil, lung cancer, stomach cancer |
Background
NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions.
Images
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Immunohistochemistry analysis of paraffin-embedded human tonsil using SIRT7 (GB11355) at dilution of 1:200. |
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Immunohistochemistry analysis of paraffin-embedded human lung cancer using SIRT7 (GB11355) at dilution of 1:200. |
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Immunohistochemistry analysis of paraffin-embedded human stomach cancer using SIRT7 (GB11355) at dilution of 1:200. |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
