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Anti-SLC39A14/ZIP-14 Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Metal cation symporter ZIP14 |
Synonyms: | Cig19, KIAA0062, ZIP14, Zrt Irt like protein 14, SLC39A14, NET34, LZT-Hs4, FAD-123, Fad123 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SLC39A14/ZIP-14 |
Uniprot ID: | Q75N73 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 54 kDa / 52 kDa |
Product Usage Information
WB | Mouse | 1: 300-1: 800 | liver |
Background
Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity. Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions. Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic. Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability. Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation. Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin.
Images
| Western blot analysis of SLC39A14 (GB114856) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
