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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Nonsense-mediated mRNA decay factor SMG5 |
Synonyms: | Est1b, Kiaa1089 |
Immunogen: | Recombinant protein corresponding to Mouse SMG5 |
Uniprot ID: | Q6ZPY2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 114 kDa / 114 kDa |
Product Usage Information
WB | Human | 1: 500-1: 2000 | Jurkat,K562 |
Background
Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity (By similarity).
Images
| WB analysis of SMG5(GB115665). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
