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Anti-SNX27 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Sorting nexin-27 |
Synonyms: | MRT1, MY014, KIAA0488, Methamphetamine responsive transcript 1, Sorting nexin family member 27 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SNX27 |
Uniprot ID: | Q3UHD6 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 61 kDa / 61 kDa |
Product Usage Information
WB | Human | 1: 1000-1: 2000 | HeLa, 293, SK-BR-3, A549 |
Background
Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex.
Images
| Western blot analysis of SNX27 (GB115046) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
