Your shopping cart is empty!
Anti-SOCS3 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SOCS3 rabbit polyclonal |
Gene Name: | Suppressor of cytokine signaling 3 |
Synonyms: | ATOD4, CIS-3, CIS3, Cish3, SOCS-3, SOCS3, SSI 3, SSI3, STAT induced STAT inhibitor 3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SOCS3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 25kDa |
Observed MW. | 25kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 300-1: 800 | brain |
Background
Suppressor of cytokine signaling 3 (SOCS3) is a member of SOCS family that these proteins induced to attenuate cytokine signal transduction in response to signals from a diverse range of cytokines and growth factors. SOCS3 is a negative regulatory protein that inhibits signaling induced by IL-6 via preventing JAK mediated activation of STAT3. However SOCS3 can positively regulate the ERK-MAPK pathway, inhibit the NF-kB pathway . In addition, SOCS3 brings a great impact on immune responses by inhibiting signaling stimulus, such as LPS, type I and type II IFNs, and IL-12. SOCS3 is widely expressed in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney .
Images
| Western blot analysis of SOCS3 (GB113792) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
