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Anti-SOCS7 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SOCS7 rabbit polyclonal antibody |
Gene Name: | Suppressor of cytokine signaling 7 |
Synonyms: | SOCS-7, Socs7, Cish7, Nap4, Ash and phospholipase C gamma-binding protein, SOCS6 |
Immunogen: | Recombinant protein corresponding to Mouse SOCS7 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Cytoplasm, Nucleus |
Uniprot ID: | Q8VHQ2 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Rat | 1: 400-1: 1300 | brain, heart, testis |
Background
SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA.
Images
| Immunohistochemistry of paraffin embedded rat brain using SOCS7 (GB111760) at dilution of 1:650 (300x lens) |
| Immunohistochemistry of paraffin embedded rat heart using SOCS7 (GB111760) at dilution of 1:650 (300x lens) |
| Immunohistochemistry of paraffin embedded rat testis using SOCS7 (GB111760) at dilution of 1:650 (300x lens) |
| Immunofluorescence of paraffin embedded rat heart using SOCS7 (GB111760) at dilution of 1:650 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
