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Anti-SPINK5/LEKTI Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SPINK5/LEKTI rabbit polyclonal antibody |
Gene Name: | Serine protease inhibitor Kazal-type 5 |
Synonyms: | Lympho-epithelial Kazal-type-related inhibitor, LEKTI, SPINK5, Hemofiltrate peptide HF7665, NETS, NS, SPINK5, VAKTI |
Immunogen: | Recombinant protein corresponding to Human SPINK5 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Uniprot ID: | Q9NQ38 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human | 1: 500-1: 2000 | cervix, tonsil |
Background
Lympho-epithelial Kazal-type inhibitor (LEKTI) is a serine protease inhibitor which protects mucous epithelia against microbial attack and inflammation. LEKTI is a marker of epithelial differentiation and expresses strongly in the granular and uppermost spinous layers of the epidermis and differentiated layers of stratified epithelia. Defects in SPINK5, the gene encoding LEKTI, are the cause of Netherton syndrome, a severe autosomal recessive disorder characterized by atopic dermatitis, hayfever and other conditions.
Images
| Immunohistochemistry of paraffin embedded human cervix using SPINK5 (GB111906) at dilution of 1:1000 (200x lens) |
| Immunohistochemistry of paraffin embedded human tonsil using SPINK5 (GB111906) at dilution of 1:1000 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
