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Anti-SRPK1 Rabbit pAb (100 μl)
| Reactivity: | R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SRPK1 rabbit polyclonal |
Gene Name: | SRSF protein kinase 1 |
Synonyms: | SFRS protein kinase 1, SFRSK1, SR protein specific kinase 1, SRPK1, Serine/arginine-rich protein-specific kinase 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse SRPK1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse | 1: 400-1: 800 | testis |
Background
SFRS protein kinase 1, SFRSK1, SR protein specific kinase 1, SRPK1SRPK1 (serine-arginine protein kinase 1) is a protein kinase that specifically phosphorylates proteins containing serine-arginine-rich domains. Its substrates include a family of SR proteins that are key regulators of mRNA AS (alternative splicing). SRPK1 may be localized both in the cytoplasm and nucleus and translocates between these compartments under various conditions (e.g. cell cycle and stress). It is able to phosphorylate SR proteins both in cytoplasm and nucleus (the significance of which remains incompletely understood) and thus regulate the activity of these proteins by affecting their ability to bind other proteins and/or RNA as well as their intracellular localization.
Images
 | Immunohistochemistry analysis of paraffin-embedded mouse testis using SRPK1 (GB113470) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
