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Anti-STRAD Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | STRAD rabbit polyclonal antibody |
Gene Name: | STE20-related kinase adapter protein alpha |
Synonyms: | STRAD alpha, STE20-related adapter protein, Strada, Lyk5, Strad |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse STRAD |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Predicted MW. | 48 kDa |
Observed MW. | 48 kDa |
Uniprot ID: | Q7RTN6, Q3UUJ4, Q7TNZ6 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain |
IHC/IF | Mouse, Rat | 1: 600-1: 1200 | corpus striatum, Skeletal muscle |
Background
LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating the tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. LYK5-LKB1 interaction results in phosphorylation of LYK5 and enhanced autophosphorylation of LKB1.
Images
| Western blot analysis of STRAD (GB112208) at dilution of 1: 500 |
| Immunofluorescence of paraffin embedded mouse corpus striatum using STRAD (GB112208) at dilution of 1: 600 (400x lens) |
| Immunofluorescence of paraffin embedded mouse skeletal muscle using STRAD (GB112208) at dilution of 1: 600 (450x lens) |
| Immunofluorescence of paraffin embedded rat skeletal muscle using STRAD (GB112208) at dilution of 1: 600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
