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Anti-STUB1/CHIP Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | STUB1/CHIP rabbit polyclonal antibody |
Gene Name: | E3 ubiquitin-protein ligase CHIP |
Synonyms: | Antigen NY-CO-7, CHIP, CLL associated antigen KW 8, HSPABP2, NY CO 7, SDCCAG7, STUB1, UBOX1, PP1131, Antigen NY CO 7, Carboxy terminus of Hsp70 interacting protein, C terminus of Hsp70-interacting protein |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse STUB1/CHIP |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 35 kDa |
Observed MW. | 35 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 1000-1: 3000 | lung, heart |
Background
STUB1, also named as CHIP, SDCCAG7, UBOX1 and NY-CO-7, is a E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. STUB1/CHIP modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. It mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. STUB1/CHIP mediates polyubiquitination of CYP3A4. CHIP/STUB1 strongly reduced keratin aggregates through increased degradation of mutant K14. STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer patients.This antibody is specific to STUB1.
Images
 | Western blot analysis of STUB1 (GB113826) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
