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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | SUN domain-containing protein 1 |
Synonyms: | KIAA0810, Protein unc 84 homolog A, Sad1/unc 84 protein like 1, SUN1, unc 84 homolog A (C. elegans), UNC84A |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human SUN1 |
Uniprot ID: | O94901 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus inner membrane |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 700-1: 2100 | placenta, brain |
Background
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton . The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity).
Images
| Immunohistochemistry analysis of paraffin embedded rat placenta using SCN1 (GB115219) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded mouse placenta using SCN1 (GB115219) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded mouse Brain using SCN1 (GB115219) at dilution of 1: 700 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
