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| Reactivity: | H,M,R & H,M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | SUN2 rabbit polyclonal |
Gene Name: | SUN domain-containing protein 2 |
Synonyms: | Protein unc-84 homolog B, Sad1/unc-84 protein-like 2, Sun2, nc84b |
Immunogen: | Recombinant protein corresponding to Mouse SUN2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Nucleus, Endosome |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 2000-1: 4000 | placenta, striatum, heart, substantia nigra |
IF | Human, Mouse, Rat | 1: 2000-1: 4000 | substantia nigra, heart, hippocampus |
Background
SUN proteins form part of the LINC complex - a protein bridge that spans the nuclear envelope linking the nucleoskeleten to the actin cytoskeleten. They are located on the inner nuclear membrane side of the complex. The LINC complex is thought to function in controlling nuclear position, contributing to mechanical resistance and the overall architecture of the cell. SUN2 can exist in a heterodimer with SUN1. Both can interact with lamins and nesprins in the nuclear envelope.
Images
| Immunohistochemistry analysis of paraffin-embedded human placenta using SUN2 (GB112747) at dilution of 1: 4000 |
| Immunohistochemistry analysis of paraffin-embedded mouse striatum using SUN2 (GB112747) at dilution of 1: 4000 |
| Immunohistochemistry analysis of paraffin-embedded mouse heart using SUN2 (GB112747) at dilution of 1: 4000 |
| Immunohistochemistry analysis of paraffin-embedded rat heart using SUN2 (GB112747) at dilution of 1: 4000 |
| Immunohistochemistry analysis of paraffin-embedded rat tsubstantia nigra using SUN2 (GB112747) at dilution of 1: 4000 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse substantia nigra using SUN2 (GB112747) at dilution of 1: 1000 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat heart using SUN2 (GB112747) at dilution of 1: 1000 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat hippocampus using SUN2 (GB112747) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
