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Anti-Scavenging Receptor SR-BI Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Scavenging Receptor SR-BI rabbit polyclonal |
Gene Name: | Scavenger receptor class B member 1 |
Synonyms: | CD36 and LIMPII analogous 1, CD36 antigen like 1, CD36L1, CLA-1, CLA1, SCARB1, SRB1, SR-B1, SR-BI |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Scavenging Receptor SR-BI |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1200-1: 2400 | kidney, liver |
Background
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI (Scavenger Receptor BI) protein binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland. Scavenging Receptor SR-BI plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer.
Images
Immunohistochemistry analysis of paraffin-embedded mouse kidney using SRB1 (GB113319) at dilution of 1: 2400 | |
| Immunohistochemistry analysis of paraffin-embedded rat kidney using SRB1 (GB113319) at dilution of 1: 2400 |
| Immunohistochemistry analysis of paraffin-embedded mouse liver using SRB1 (GB113319) at dilution of 1: 2400 |
| Immunohistochemistry analysis of paraffin-embedded rat liver using SRB1 (GB113319) at dilution of 1: 2400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
