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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Mothers against decapentaplegic homolog 2 |
Synonyms: | JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD family member 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Smad2 |
Uniprot ID: | Q62432 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 49-52 kDa / 49-60 kDa |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | heart, skeletal muscle |
Background
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).
Images
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Western blot analysis of Smad2 (GB11172) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
