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Anti-Staufen/STAU1 Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Staufen/STAU1 rabbit polyclonal antibody |
Gene Name: | Double-stranded RNA-binding protein Staufen homolog 1 |
Synonyms: | Stau1, Stau, staufen, Staufen RNA binding protein homolog 1, PPP1R150, FLJ25010, Staufen/STAU1 |
Immunogen: | Recombinant protein corresponding to Mouse Staufen/STAU1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 54 kDa |
Observed MW. | 54 kDa |
Uniprot ID: | O95793, Q9Z108 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse | 1: 500-1: 1000 | HepG2, A-431, K562, NIH/3T3 |
Background
Staufen1 (STAU1)-mediated mRNA decay (SMD) degrades translationally active mRNAs that bind the double-stranded (ds)RNA binding protein STAU1 within their 3'-untranslated regions (3'UTRs) [PMID:21307942]. STAU1 can binds to stem structures and protect Dvl2 mRNA from degradation by associating with the secondary structure in the U1 region which is located at 5′ position of second U stretch in the U2 region [PMID:17510634]. It has a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
Images
| Western blot analysis of Stau1 (GB111924) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
