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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Syk rabbit polyclonal antibody |
Gene Name: | Tyrosine-protein kinase SYK |
Synonyms: | Syk, SYK, p72-Syk, spleen tyrosine kinase, spleen associated tyrosine kinase |
Immunogen: | Recombinant protein corresponding to Mouse Syk |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 72 kDa |
Observed MW. | 75 kDa |
Uniprot ID: | P43405, P48025, Q64725 |
Product Usage Information
| Applications | Species | Dilution | Positive Tissue |
| WB | Human, Mouse, Rat | 1: 500-1: 1000 | spleen, lung, lymph gland |
Background
Spleen tyrosine kinase, also known as Syk, is an enzyme encoded by the SYK gene. SYK, along with Zap-70, is a member of the Syk family of tyrosine kinases. These non-receptor cytoplasmic tyrosine kinases share a characteristic dual SH2 domain separated by a linker domain. However, activation of SYK relies less on phosphorylation by Src family kinases than Zap-70. While Syk and Zap-70 are primarily expressed in hematopoietic tissues, there is expression of Syk in a variety of tissues. Within B and T cells respectively, Syk and Zap-70 transmit signals from the B-Cell receptor and T-Cell receptor. Syk plays a similar role in transmitting signals from a variety of cell surface receptors including CD74, Fc Receptor, and integrins.
Images
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Western blot analysis of Syk (GB11789) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
