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Anti-TANK/TRAF2 Rabbit pAb (100 μl)
| Reactivity: | M,R & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TANK/TRAF2 rabbit polyclonal antibody |
Gene Name: | TRAF family member-associated NF-kappa-B activator |
Synonyms: | TRAF-interacting protein, I-TRAF, Tank, Itraf |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TRAF2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Predicted MW. | 51 kDa |
Observed MW. | 45 kDa |
Uniprot ID: | Q92844, P70347 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | brain, heart |
IHC/IF | Human | 1: 500-1: 1000 | colon cancer, kidney, liver cancer, lung |
Background
Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity.
Images
| Western blot analysis of ITRAF (GB112338) at dilution of 1: 500 |
 | Immunofluorescence of paraffin embedded human colon cancer using ITRAF (GB112338) at dilution of 1: 600 (400x lens) |
| Immunofluorescence of paraffin embedded human kidney using ITRAF (GB112338) at dilution of 1: 600 (400x lens) |
| Immunofluorescence of paraffin embedded human liver cancer using ITRAF (GB112338) at dilution of 1: 600 (400x lens) |
| Immunofluorescence of paraffin embedded human lung using ITRAF (GB112338) at dilution of 1: 600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
