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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TAP2 rabbit polyclonal |
Gene Name: | Antigen peptide transporter 2 |
Synonyms: | ATP-binding cassette sub-family B member 3, Histocompatibility antigen modifier 2, APT2, Tap2, Abcb3, Ham-2, Ham2, ABC18, PSF2, RING 11, Peptide transporter TAP2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TAP2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 77 kDa |
Observed MW. | 77 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 300-1: 600 | HeLa, MCF-7, U-2 OS, HT-29, T47D |
Background
TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It is a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP is inducible by interferon gamma and belongs to the ABC transporter family, MDR subfamily. TAP also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP.
Images
 | Western blot analysis of TAP2 (GB113273) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
