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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TAZ rabbit polyclonal antibody |
Gene Name: | WW domain-containing transcription regulator protein 1 |
Synonyms: | Transcriptional coactivator with PDZ-binding motif, Wwtr1, Taz, WW domain containing transcription regulator protein 1, DKFZP586I1419 |
Immunogen: | Recombinant protein corresponding to Mouse TAZ |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | Q9EPK5 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1:700-1:1400 | lung, placenta |
Background
TAZ, also referred as WWTR1, is a transcriptional co-activator with a PDZ-binding motif that is regulated by its interaction with 14-3-3 protein. TAZ is expressed in many primary tumors, such as breast cancer, thyroid carcinoma, colorectal cancer, and glioma. TAZ has been reported to be one of the nuclear effectors of Hippo-related pathways that regulate organ size control, cancer stem cell (CSC) properties, and epithelial–mesenchymal transition (EMT).
Images
| Immunohistochemistry of paraffin embedded mouse placenta using Wwtr1 (GB111753) at dilution of 1:700 (300x lens) |
| Immunohistochemistry of paraffin embedded rat placenta using Wwtr1 (GB111753) at dilution of 1:700 (300x lens) |
| Immunofluorescence of paraffin embedded mouse placenta using Wwtr1 (GB111753) at dilution of 1:700 (300x lens) |
| Immunofluorescence of paraffin embedded rat lung using Wwtr1 (GB111753) at dilution of 1:700 (300x lens) |
 | Immunofluorescence of paraffin embedded rat placenta using Wwtr1 (GB111753) at dilution of 1:700 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
