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| Reactivity: | H |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TCRb rabbit polyclonal |
Gene Name: | M1-specific T cell receptor beta chain |
Synonyms: | |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human TCRb |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 50-1: 100 | colon cancer, lung cancer, tonsil |
Background
Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells .
Images
| Immunohistochemistry analysis of paraffin-embedded human colon cancer using TCRb (GB113149) at dilution of 1: 1800 |
| Immunohistochemistry analysis of paraffin-embedded human lung cancer using TCRb (GB113149) at dilution of 1: 1800 |
| Immunohistochemistry analysis of paraffin-embedded human tonsil using TCRb (GB113149) at dilution of 1: 1800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
