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Anti-TIP49A Rabbit pAb (100 μl)
| Reactivity: | H,R & H,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | RuvB-like 1 |
Synonyms: | 49 kDa TATA box-binding protein-interacting protein, 49 kDa TBP-interacting protein, DNA helicase p50, Pontin 52, TIP49A, Tip49, Ruvbl1 |
Immunogen: | Recombinant protein corresponding to Mouse TIP49A |
Uniprot ID: | P60122 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. / Observed MW. | 50 kDa / 55 kDa |
Product Usage Information
WB | Human, Rat | 1: 500-1: 1000 | colon |
IHC/IF | Human, Rat | 1: 300-1: 600 | kidney |
Background
RUVBL1 is a member of the AAA (ATPase associated with diverse cellular activities) family of proteins that is associated with several chromatin-remodelling complexes and has important roles in transcriptional regulation, the DNA damage response, telomerase activity, snoRNP assembly, cellular transformation and cancer metastasis[PMID: 21617703]. It consists of 456 amino acids (50 kDa) and interacts with TATA-binding protein (TBP), which is a central component for transcriptional regulation by forming complexes with various transcription regulators.
Images
| Western blot analysis of TIP49A (GB111869) at dilution of 1: 1000 |
| Immunofluorescence analysis of paraffin embedded rat kidney using TIP49A (GB111869) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
