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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TLE 1 rabbit polyclonal antibody |
Gene Name: | Transducin-like enhancer protein 1 |
Synonyms: | Tle1, TLE1, ESG, ESG1, GRG1, Transducin like enhancer of split 1, TLE family member 1, transcriptional corepressor |
Immunogen: | Recombinant protein corresponding to Mouse TLE 1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 75 kDa |
Observed MW. | 75 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | kidney, colon, stomach, prostate |
Background
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Images
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Western blot analysis of TLE-1 (GB11898) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
