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Anti-TMS1/ASC Rabbit pAb (100 μl)
| Reactivity: | M & M |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | PYD and CARD domain containing |
Synonyms: | ASC, CARD5, hASC, PYCARD, PYD and CARD domain containing, TMS, TMS 1, TMS1 |
Immunogen: | Recombinant protein corresponding to Mouse TMS1/ASC |
Uniprot ID: | Q9EPB4 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Predicted MW. / Observed MW. | 22 kDa / 22-25 kDa |
Product Usage Information
WB | Mouse | 1: 500-1: 1500 | spleen, lymph node, small intestine |
IHC/IF | Mouse | 1: 2000-1: 4000 | small intestine, lung injury |
Background
PYCARD , also known as ASC or TMS1, is a 195 amino acid protein containing an N-terminal Pyrin-like domain (PYD) and an 87 residue C-terminal Caspase-associated recruitment domain (CARD). It promotes caspase-mediated apoptosis which is mediated predominantly through the activation of caspase-9.
Images
 | Western blot analysis of ASC (GB113966) at dilution of 1: 1000 |
| Immunohistochemistry of paraffin embedded mouse inflammatory model induced by lps(24h) small intestine using ASC (GB113966) at dilution of 1: 4000 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse lung injury using ASC (GB113966) at dilution of 1: 4000 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse small intestine using ASC (GB113966) at dilution of 1: 4000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
