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Anti-TNF-alpha Rabbit pAb (100 μl)
| Reactivity: | R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Tumor necrosis factor alpha |
Synonyms: | TNF, DIF, TNF-alpha,T NFA, TNFSF2, Tumour necrosis factor, Tumour necrosis factor alpha,tumor necrosis factor, TNLG1, TNF-α, TNF a, TNF alpha, NFα, TNF-α, Cachectin |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TNF-α |
Uniprot ID: | P06804 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Secreted |
Product Usage Information
Applications | Species | Dilution | Positive Tissue |
IHC/IF | Rat | 1: 500-1: 1000 | Sepsis lung |
Background
TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.
Images
| IHC analysis of TNF-alpha(GB115701). |
| IHC analysis of TNF-alpha(GB115701). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol. |
