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Anti-TORC2 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TORC2 rabbit polyclonal |
Gene Name: | CREB-regulated transcription coactivator 2 |
Synonyms: | CRTC2, RP11 422P24.6, TORC-2, TORC2, Transducer of CREB protein 2, Transducer of regulated cAMP response element-binding protein 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TORC2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 73 kDa |
Observed MW. | 85 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse | 1: 300-1: 600 | brain |
Background
CRTC2, also named as TORC2, belongs to the TORC family. It is a transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. It acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. CRTC2 enhances the interaction of CREB1 with TAF4. Ir regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. CRTC2 regulates the expression of specific genes such as the steroidogenic gene, StAR. TORC2 was recently shown to be an important regulator of gluconeogenesis in the livers of mammals. It is one of the other key regulators of CRE-dependent MIE gene expression in NT2 cells.
Images
 | Western blot analysis of TORC2 (GB113668) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
