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Anti-TRIM13 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | E3 ubiquitin-protein ligase TRIM13 |
Synonyms: | B cell chronic lymphocytic leukemia tumor suppressor Leu5, CAR, DLEU5, HGNC:9976, LEU5, Leukemia associated protein 5, Putative tumor suppressor RFP2, Ret finger protein 2, RING finger protein 77, RNF77, TRIM13, Tripartite motif protein 13 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TRIM13 |
Uniprot ID: | Q9CYB0 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 47 kDa / 47 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 400-1: 800 | testis |
Background
Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. Plays also a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway.
Images
| Western blot analysis of TRIM13 (GB114628) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
