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Anti-TRIM21/SS-A Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TRIM21/SS-A rabbit polyclonal |
Gene Name: | E3 ubiquitin-protein ligase TRIM21 |
Synonyms: | 52 kDa Ro protein, RING finger protein 81, RNF81, Ro(SS A), RO52, SS-A, SSA, SSA1, TRIM21, tripartite motif containing 21, Sjoegren syndrome type A antigen |
Immunogen: | Recombinant protein corresponding to Mouse TRIM21/SS-A |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 700-1: 1400 | stomach |
Background
TRIM21 has multiple N-terminal zinc finger motifs(has E3 ligase activity), a central leucine zipper, and a potential N-glycosylation site. TRIM3 is a E3 ubiquitin-protein ligase. It can form a ubiquitin ligase complex with E2 UBE2D2, which function not only for the uniquitination of USP4 and IKBKB but also for its self-ubiquitination. It has a role in the regulation of the cell cycle progression and could enhance the decapping activity of DCP2. It can exist in all mammalian cells as a ribonucleoprotein particle , which composed of a single polypeptide and 1 of 4 small RNA molecules. TRIM21 exists various isoforms and range molecular weight of isoforms is about 42-45kDa and 49-54 kDa.
Images
 | Immunohistochemistry analysis of paraffin-embedded human stomach using TRIM21 (GB113486) at dilution of 1: 1400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
