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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | E3 ubiquitin-protein ligase TRAIP |
Synonyms: | RING finger protein 206, RNF206, TRAF interacting protein, TRAIP, TRIP |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TRIP |
Uniprot ID: | Q8VIG6 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 53 kDa / 55 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | colon, brain |
Background
E3 ubiquitin ligase required to protect genome stability in response to replication stress . Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription . Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex . Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 . If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway .
Images
| Western blot analysis of TRAIP (GB114626) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
