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| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | TYK2 rabbit polyclonal |
Gene Name: | Non-receptor tyrosine-protein kinase TYK2 |
Synonyms: | Tyk2, JTK1, Protein Tyrosine Kinase 2, Tyrosine kinase 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse TYK2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoskeleton, Cytoplasm |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 400-1: 800 | liver, spleen, kidney |
IF | Mouse, Rat | 1: 200-1: 400 | spleen |
Background
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse liver using TYK2 (GB112525) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin-embedded rat liver using TYK2 (GB112525) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin-embedded mouse spleen using TYK2 (GB112525) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin-embedded rat spleen using TYK2 (GB112525) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin-embedded rat kidney using TYK2 (GB112525) at dilution of 1: 800 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse spleen using TYK2 (GB112525) at dilution of 1: 400 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat spleen using TYK2 (GB112525) at dilution of 1: 400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
