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| Reactivity: | R & R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Tal1 rabbit polyclonal |
Gene Name: | T-cell acute lymphocytic leukemia protein 1 homolog |
Synonyms: | Tal1, TAL1, SCL, TCL5, bHLHa17, tal-1, T-cell acute lymphocytic leukemia 1, TAL bHLH transcription factor 1, erythroid differentiation factor |
Immunogen: | Recombinant protein corresponding to Mouse Tal1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Rat | 1: 800-1: 1500 | hepatitis, spleen |
IF | Rat | 1: 400-1: 1000 | hepatitis, spleen |
Background
Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase alpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.
Images
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Immunohistochemistry analysis of paraffin-embedded rat hepatitis using Tal1 (GB11885) at dilution of 1: 1500 |
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Immunohistochemistry analysis of paraffin-embedded rat spleen using Tal1 (GB11885) at dilution of 1: 1500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
