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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Microtubule-associated protein tau |
Synonyms: | Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, DDPAC, FTDP 17, MAPTL, RNPTAU, PPP1R103, Paired helical filament-tau |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Tau |
Uniprot ID: | P10637 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Cell membrane |
Predicted MW. / Observed MW. | 79 kDa / 50-80 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, spleen |
IHC/IF | Human, Mouse, Rat | 1: 100-1: 500 | brain |
Background
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Images
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Western blot analysis of Tau (GB11178) at dilution of 1: 1000 |
| Western blot analysis of Tau (GB11178) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using Tau(GB11178) at dilution of 1:100 |
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Immunohistochemistry analysis of paraffin-embedded human brain using Tau(GB11178) at dilution of 1:100 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
