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| Reactivity: | M,R & R |
| Applications: | WB & IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Tin2 rabbit polyclonal |
Gene Name: | TERF1-interacting nuclear factor 2 |
Synonyms: | TRF1-interacting nuclear protein 2, Tinf2, Tin2, DKCA3, MGC94711 |
Immunogen: | Recombinant protein corresponding to Mouse Tin2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. | 38 kDa |
Observed MW. | 43 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
| WB | Mouse, Rat | 1: 500-1: 1000 | heart |
| IHC | Rat | 1: 3800-1: 7600 | heart |
Background
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly.
Images
 | Western blot analysis of Tin2 (GB113181) at dilution of 1: 1000 |
 | Immunohistochemistry analysis of paraffin-embedded rat heart using Tin2 (GB113181) at dilution of 1: 7600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
