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Anti-Topoisomerase II alpha Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Topoisomerase II alpha rabbit polyclonal antibody |
Gene Name: | DNA topoisomerase 2-alpha |
Synonyms: | DNA topoisomerase II, alpha isozyme, TOP2A, Top-2, Top2 |
Immunogen: | Recombinant protein corresponding to Mouse Top2a |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | Q01320, P41516 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 2000 | brain, ovary, thymus, thymus+LPS |
Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event.
Images
 | Immunohistochemistry of paraffin embedded mouse brain using Top2 (GB111031) at dilution of 1:600 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse ovary using Top2 (GB111031) at dilution of 1:5000 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse ovary using Top2 (GB111031) at dilution of 1:600 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse thymus using Top2 (GB111031) at dilution of 1:5000 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse thymus using Top2 (GB111031) at dilution of 1:600 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat brain using Top2 (GB111031) at dilution of 1:600 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat ovary using Top2 (GB111031) at dilution of 1:5000 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat ovary using Top2 (GB111031) at dilution of 1:600 (400x lens) |
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Immunohistochemistry of paraffin embedded rat thymus+LPS using Top2 (GB111031) at dilution of 1:5000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat thymus+LPS using Top2 (GB111031) at dilution of 1:600 (400x lens) |
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Immunofluorescence of paraffin embedded mouse ovary using Top2 (GB111031) at dilution of 1:500 (400x lens) |
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Immunofluorescence of paraffin embedded rat thymus using Top2 (GB111031) at dilution of 1:500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
