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Anti-Torsin A/DYT1 Rabbit pAb (100 μl)
| Reactivity: | M,R & H,R & H,R |
| Applications: | WB & IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Torsin A rabbit polyclonal |
Gene Name: | Torsin-1A |
Synonyms: | Dystonia 1 protein, Torsin ATPase 1, Torsin family 1 member A, Tor1a, Dyt1, Torsin A |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Torsin A |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 38 kDa |
Observed MW. | 38 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | kidney, liver |
IHC | Human, Rat | 1: 800-1: 1600 | colon cancer, ovary cancer, esophageal cancer, testis |
IF | Human, Rat | 1: 1500-1: 3000 | brain nigra |
Background
TOR1A (torsin A), also known as DYT1 is a member of the AAA family of adenosine triphosphatases (ATPases) that mediate chaperone and other functions involved in conformational modeling of proteins, protection from stress, and targeting of proteins to cellular organelles. TOR1A primarily localizes to the ER while exposure to oxidative stress causes the redistribution to cell surface protrusions. Mutations in gene encoding TOR1A cause the most severe form of hereditary dystonia, termed early onset, generalized dystonia.
Images
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Western blot analysis of Torsin A (GB111294) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded human colon cancer using Torsin A (GB111294) at dilution of 1: 800 |
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Immunohistochemistry analysis of paraffin-embedded human ovary cancer using Torsin A (GB111294) at dilution of 1:800 |
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Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using Torsin A (GB111294) at dilution of 1: 800 |
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Immunohistochemistry analysis of paraffin-embedded rat testis using Torsin A (GB111294) at dilution of 1: 800 |
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Immunofluorescent analysis of paraformaldehyde-fixed rat brain nigra using Torsin A (GB111294) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
