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Anti-Twinkle Rabbit pAb (100 μl)
| Reactivity: | R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Twinkle rabbit polyclonal antibody |
Gene Name: | Twinkle protein, mitochondrial |
Synonyms: | Progressive external ophthalmoplegia 1 protein homolog, T7 gp4-like protein with intramitochondrial nucleoid localization, T7-like mitochondrial DNA helicase, Twinkle mtDNA helicase, Twnk, Peo1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Twinkle |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Mitochondrion |
Predicted MW. | 77 kDa |
Observed MW. | 72 kDa |
Uniprot ID: | Q8CIW5 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Rat | 1: 500-1: 1000 | pancreas |
IHC/IF | Mouse, Rat | 1: 500-1: 1600 | kidney |
Background
Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals.
Images
| Western blot analysis of TWNK (GB112301) at dilution of 1: 500 |
 | Immunohistochemistry of paraffin embedded mouse kidney using TWNK (GB112301) at dilution of 1: 600 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat kidney using TWNK (GB112301) at dilution of 1: 600 (400x lens) |
| Immunofluorescence of paraffin embedded rat kidney using TWNK (GB112301) at dilution of 1: 600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
