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Anti-UBE2M/UBC12 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | UBE2M/UBC12 rabbit polyclonal antibody |
Gene Name: | NEDD8-conjugating enzyme Ubc12 |
Synonyms: | NEDD8 carrier protein, Ubiquitin-conjugating enzyme E2 M, Ube2m, Ubc-rs2, Ubc12, hUbc12, yeast UBC12 homolog |
Immunogen: | Recombinant protein corresponding to Mouse UBE2M/UBC12 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 21 kDa |
Observed MW. | 21 kDa |
Uniprot ID: | P61081, P61082 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 1000-1: 2000 | testis, brain |
Background
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
Images
 | Western blot analysis of UBC12 (GB112655) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
