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Anti-UBE3A Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | UBE3A rabbit polyclonal antibody |
Gene Name: | Ubiquitin-protein ligase E3A |
Synonyms: | HECT-type ubiquitin transferase E3A, Oncogenic protein-associated protein E6-AP, Ube3a, Renal carcinoma antigen NY REN 54, HPVE6A, FLJ26981 |
Immunogen: | Recombinant protein corresponding to Mouse UBE3A |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | Q05086, O08759 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 100-1: 1000 | brain, kidney, lung, lung cancer, spleen, thymus |
Background
UBE3A (ubiquitin-protein ligase E3A, AKA E6AP) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A, RAD23B, MCM7, annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, UBE3A may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins.
Images
| Immunohistochemistry of paraffin embedded mouse brain using UBE3A (GB112462) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse kidney using UBE3A (GB112462) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse lung using UBE3A (GB112462) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded rat brain using UBE3A (GB112462) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded rat kidney using UBE3A (GB112462) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded rat lung using UBE3A (GB112462) at dilution of 1:500 (400x lens) |
| Immunofluorescence of paraffin embedded human lung cancer using UBE3A (GB112462) at dilution of 1:650 (400x lens) |
| Immunofluorescence of paraffin embedded mouse brain using UBE3A (GB112462) at dilution of 1:650 (400x lens) |
| Immunofluorescence of paraffin embedded rat lung using UBE3A (GB112462) at dilution of 1:650 (400x lens) |
| Immunofluorescence of paraffin embedded rat spleen using UBE3A (GB112462) at dilution of 1:650 (400x lens) |
| Immunofluorescence of paraffin embedded rat thymus using UBE3A (GB112462) at dilution of 1:650 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
