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Anti-UCHL3 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L3 |
Synonyms: | Ubiquitin carboxyl terminal hydrolase isozyme L3, Ubiquitin thioesterase L3, UCHL3, UCH-L3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse UCHL3 |
Uniprot ID: | Q9JKB1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 26 kDa / 26 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 1000-1: 2000 | brain, testis |
Background
Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis.
Images
| Western blot analysis of UCHL3 (GB115268) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
