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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | UMOD rabbit polyclonal antibody |
Gene Name: | Uromodulin |
Synonyms: | Tamm-Horsfall urinary glycoprotein, THP, Umod, ADMCKD2, FJHN , urehr4, HNFJ1, THGP |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse UMOD |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted, Cell membrane |
Uniprot ID: | P07911, Q91X17 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1:1500-1:3000 | kidney |
Background
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria.
Images
| Immunohistochemistry analysis of paraffin-embedded human kidney using UMOD (GB112167) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded mouse kidney using UMOD (GB112167) at dilution of 1: 3000 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse kidney using UMOD (GB112167) at dilution of 1: 3000 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat kidney using UMOD (GB112167) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
